| Gene Information | |
|---|---|
| Gene Name | MAL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 176 |
| Protein Names | Protein MAL2 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000147676 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q969L2 |
| Gene Card | MAL2 |
| Uniprot ID | Q969L2 |
| Pfam | PF01284 |
| In ASD | no |
| Allosteric Prediction | no (-1.260645166) |
| Ortholog in Animals | Alpaca_ MAL2 ( ortholog_one2one ) Dog_ MAL2 ( ortholog_one2one ) GuineaPig_ MAL2 ( ortholog_one2one ) Macaque_ MAL2 ( ortholog_one2one ) Mouse_ Mal2 ( ortholog_one2one ) Pig_ MAL2 ( ortholog_one2one ) Rat_ Mal2 ( ortholog_one2one ) Rabbit_ MAL2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CMTM2, PLP2, MAL, CMTM3, PLLP, CMTM4, CMTM8, CMTM1, CMTM7, CKLF, MALL, CMTM6, MARVELD1, CMTM5 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine. {ECO:0000269|PubMed:11549320, ECO:0000269|PubMed:14576188}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2303398 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endomembrane system. Cytoplasm, perinuclear region. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma Hep-G2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized Hep-G2 cells, distributed to the perinuclear region. |
| Mouse PG classification | NA |
| click here to return to the previous page | |