| Gene Information | |
|---|---|
| Gene Name | MAL |
| Organism | Homo sapiens (Human) |
| Gene Length | 221 |
| Protein Names | Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000172005 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P58753 |
| Gene Card | TIRAP |
| Uniprot ID | P58753 |
| Pfam | PF13676 |
| In ASD | no |
| Allosteric Prediction | no (-0.517615198) |
| Ortholog in Animals | Alpaca_ MAL ( ortholog_one2one ) Dog_ MAL ( ortholog_one2one ) GuineaPig_ MAL ( ortholog_one2one ) Macaque_ MAL ( ortholog_one2one ) Mouse_ Mal ( ortholog_one2one ) Rat_ Mal ( ortholog_one2one ) Rabbit_ MAL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CMTM2, PLP2, CMTM3, PLLP, CMTM4, CMTM8, CMTM1, MAL2, CMTM7, CKLF, MALL, CMTM6, MARVELD1, CMTM5 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2NDH (NMR - ) 2Y92 (X-ray 3.01A ) 3UB2 (X-ray 2.40A ) 3UB3 (X-ray 2.75A ) 3UB4 (X-ray 3.10A ) 4FZ5 (X-ray 3.60A ) 4LQD (X-ray 2.45A ) 5T7Q (NMR - ) 5UZB (EM 7.00A ) |
| DBSNP | rs8177369 rs8177399 rs3802813 rs8177400 rs8177374 rs7932976 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19948740}. Cell membrane {ECO:0000269|PubMed:19948740}. Membrane {ECO:0000269|PubMed:19948740}. Note=Colocalizes with DAB2IP at the plasma membrane. |
| Mouse PG classification | NA |
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