| Gene Information | |
|---|---|
| Gene Name | MAL |
| Organism | Homo sapiens (Human) |
| Gene Length | 931 |
| Protein Names | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000172005 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q969V6 |
| Gene Card | MRTFA |
| Uniprot ID | Q969V6 |
| Pfam | PF02755; PF02037 |
| In ASD | no |
| Allosteric Prediction | no (-0.517615198) |
| Ortholog in Animals | Alpaca_ MAL ( ortholog_one2one ) Dog_ MAL ( ortholog_one2one ) GuineaPig_ MAL ( ortholog_one2one ) Macaque_ MAL ( ortholog_one2one ) Mouse_ Mal ( ortholog_one2one ) Rat_ Mal ( ortholog_one2one ) Rabbit_ MAL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CMTM2, PLP2, CMTM3, PLLP, CMTM4, CMTM8, CMTM1, MAL2, CMTM7, CKLF, MALL, CMTM6, MARVELD1, CMTM5 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain (PubMed:11344311). Expressed in peripheral blood mononuclear cells (at protein level) (PubMed:26224645). {ECO:0000269|PubMed:11344311, ECO:0000269|PubMed:26224645}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2KVU (NMR - ) 2KW9 (NMR - ) |
| DBSNP | rs878756 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:24440334}. Nucleus {ECO:0000269|PubMed:19350017, ECO:0000269|PubMed:24440334}. Note=Subcellular location is tightly regulated by actin both in cytoplasm and nucleus: high levels of G-actin in the nucleus observed during serum deprivation lead to low levels of nuclear MRTFA, while reduced levels of nuclear G-actin result in accumulation of MRTFA in the nucleus (By similarity). G-actin-binding in the cytoplasm inhibits nuclear import by masking the nuclear localization signal (NLS) (By similarity). In contrast, binding to nuclear globular actin (G-actin) promotes nuclear export to the cytoplasm (By similarity). Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear actin, which decreases nuclear G-actin pool, thereby promoting retention of MRTFA in the nucleus and subsequent formation of an active complex with SRF (PubMed:24440334). {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:24440334}. |
| Mouse PG classification | NA |
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