| Gene Information | |
|---|---|
| Gene Name | MAL |
| Organism | Homo sapiens (Human) |
| Gene Length | 235 |
| Protein Names | T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000172005 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P01732 |
| Gene Card | CD8A |
| Uniprot ID | P01732 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.517615198) |
| Ortholog in Animals | Alpaca_ MAL ( ortholog_one2one ) Dog_ MAL ( ortholog_one2one ) GuineaPig_ MAL ( ortholog_one2one ) Macaque_ MAL ( ortholog_one2one ) Mouse_ Mal ( ortholog_one2one ) Rat_ Mal ( ortholog_one2one ) Rabbit_ MAL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CMTM2, PLP2, CMTM3, PLLP, CMTM4, CMTM8, CMTM1, MAL2, CMTM7, CKLF, MALL, CMTM6, MARVELD1, CMTM5 |
| Tissue | NA |
| Tissue Specificity | CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation. {ECO:0000269|PubMed:16236125, ECO:0000269|PubMed:17678538, ECO:0000269|PubMed:26082771}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003212(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1AKJ (X-ray 2.65A ) 1CD8 (X-ray 2.60A ) 1Q69 (NMR - ) 2HP4 (X-ray 2.10A ) 3QZW (X-ray 2.80A ) 7UMG (X-ray 2.40A ) |
| DBSNP | rs121918660 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:1460019, ECO:0000269|PubMed:17341584, ECO:0000269|PubMed:17678538}; Single-pass type I membrane protein. Note=CD8A localizes to lipid rafts only when associated with its partner CD8B. {ECO:0000269|PubMed:17341584}.; [Isoform 2]: Secreted {ECO:0000269|PubMed:7923932}. |
| Mouse PG classification | NA |
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