| Gene Information | |
|---|---|
| Gene Name | MAK |
| Organism | Homo sapiens (Human) |
| Gene Length | 623 |
| Protein Names | Serine/threonine-protein kinase MAK (EC 2.7.11.1) (Male germ cell-associated kinase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000111837 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P20794 |
| Gene Card | MAK |
| Uniprot ID | P20794 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.453283317) |
| Ortholog in Animals | Alpaca_ MAK ( ortholog_one2one ) Dog_ MAK ( ortholog_one2one ) GuineaPig_ MAK ( ortholog_one2one ) Macaque_ MAK ( ortholog_one2one ) Mouse_ Mak ( ortholog_one2one ) Pig_ MAK ( ortholog_one2one ) Rat_ Mak ( ortholog_one2one ) Rabbit_ MAK ( ortholog_one2one ) |
| Ohnologs | CILK1 |
| Paralogs | MAPK8, MAPK10, MAPK1, MAPK6, MAPK12, MAPK13, SRPK1, SRPK3, MAPK4, NLK, MAPK14, MAPK3, MOK, MAPK11, MAPK15, MAPK7, SRPK2, MAPK9, CILK1 |
| Tissue | medulla.oblongata, pineal.gland, testis |
| Tissue Specificity | Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors. {ECO:0000269|PubMed:12084720, ECO:0000269|PubMed:21825139}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs387906647 rs754916169 rs387906646 rs387906648 rs750559316 rs56215624 rs371971492 rs17579447 rs55773478 rs567083 rs56217305 |
| Subcellular location [CC] | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Photoreceptor inner segment. Note=Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase. {ECO:0000250}. |
| Mouse PG classification | NA |
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