| Gene Information | |
|---|---|
| Gene Name | CCR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 355 |
| Protein Names | C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191) |
| Target Name | c-c chemokine receptor type 1 |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000163823 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P32246 |
| Gene Card | CCR1 |
| Uniprot ID | P32246 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.892411805) |
| Ortholog in Animals | Alpaca_ CCR1 ( ortholog_one2one ) Dog_ CCR1 ( ortholog_one2one ) Macaque_ CCR1 ( ortholog_one2one ) Mouse_ Ccr1 ( ortholog_one2many ) Mouse_ Ccr1l1 ( ortholog_one2many ) Pig_ CCR1 ( ortholog_one2one ) Rat_ Ccr1l1 ( ortholog_one2one ) Rabbit_ CCR1 ( ortholog_one2one ) |
| Ohnologs | CCR7 |
| Paralogs | CCR9, CXCR6, CCR7, CCR6, ACKR4, CCR10, CXCR5, CXCR4, CXCR1, CXCR2, CXCR3, GALR2, XCR1, RGR, ACKR3, CCR3, CCRL2, CCR2, CCR5, CCR4, CCR8, CX3CR1, ACKR2 |
| Tissue | spleen, whole.blood |
| Tissue Specificity | Widely expressed in different hematopoietic cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7VL8 (EM 2.90A ) 7VL9 (EM 2.60A ) 7VLA (EM 2.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18587271}; Multi-pass membrane protein {ECO:0000269|PubMed:18587271}. |
| Mouse PG classification | NA |
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