| Gene Information | |
|---|---|
| Gene Name | SGK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 431 |
| Protein Names | Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) |
| Target Name | serine/threonine-protein kinase sgk1 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000118515 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00141 |
| Gene Card | SGK1 |
| Uniprot ID | O00141 |
| Pfam | PF00069; PF00433 |
| In ASD | no |
| Allosteric Prediction | yes (1.475778869) |
| Ortholog in Animals | Alpaca_ SGK1 ( ortholog_one2one ) Dog_ SGK1 ( ortholog_one2one ) Macaque_ SGK1 ( ortholog_one2one ) Mouse_ Sgk1 ( ortholog_one2one ) Pig_ SGK1 ( ortholog_one2one ) Rat_ Sgk1 ( ortholog_one2one ) Rabbit_ SGK1 ( ortholog_one2one ) |
| Ohnologs | SGK2, SGK3 |
| Paralogs | STK32B, MAST3, STK32A, MAST2, LATS2, MAST4, SGK2, SGK3, LATS1, STK32C, MAST1, DMPK, MASTL |
| Tissue | NA |
| Tissue Specificity | Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal muscle. {ECO:0000269|PubMed:10548550, ECO:0000269|PubMed:18753299}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2R5T (X-ray 1.90A ) 3HDM (X-ray 2.60A ) 3HDN (X-ray 3.10A ) 7PUE (X-ray 2.51A ) |
| DBSNP | rs34133418 rs55932330 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Cell membrane. Mitochondrion. Note=The subcellular localization is controlled by the cell cycle, as well as by exposure to specific hormones and environmental stress stimuli. In proliferating cells, it shuttles between the nucleus and cytoplasm in synchrony with the cell cycle, and in serum/growth factor-stimulated cells it resides in the nucleus. In contrast, after exposure to environmental stress or treatment with glucocorticoids, it is detected in the cytoplasm and with certain stress conditions is associated with the mitochondria. In osmoregulation through the epithelial sodium channel, it can be localized to the cytoplasmic surface of the cell membrane. Nuclear, upon phosphorylation.; [Isoform 2]: Cell membrane. |
| Mouse PG classification | NA |
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