| Gene Information | |
|---|---|
| Gene Name | MAGEE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 373 |
| Protein Names | Melanoma-associated antigen C2 (Cancer/testis antigen 10) (CT10) (Hepatocellular carcinoma-associated antigen 587) (MAGE-C2 antigen) (MAGE-E1 antigen) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000198934 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UBF1 |
| Gene Card | MAGEC2 |
| Uniprot ID | Q9UBF1 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.689881741) |
| Ortholog in Animals | Alpaca_ MAGEE1 ( ortholog_one2many ) GuineaPig_ MAGEE1 ( ortholog_one2one ) Macaque_ MAGEE1 ( ortholog_one2one ) Mouse_ Magee1 ( ortholog_one2one ) Rat_ Magee1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MAGED4, MAGED4B, MAGEB17, MAGEB1, MAGEA3, MAGEA6, MAGEL2, MAGEA2, MAGEA2B, MAGEA12, NDN, MAGEB6, MAGEB6B, MAGEB2, MAGEH1, MAGEA8, MAGEE2, MAGEA11, MAGEB5, MAGED1, MAGEB10, MAGEA10, MAGEA4, TRO, MAGEB4, MAGEC3, MAGEA9, MAGEA9B, MAGEB3, MAGEC1, MAGEC2, NSMCE3, MAGEA1, MAGEB18, MAGEB16, MAGEF1, MAGED2 |
| Tissue | cerebral.cortex |
| Tissue Specificity | Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is an inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression. {ECO:0000269|PubMed:12097419, ECO:0000269|PubMed:12920247}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12920247}. Nucleus {ECO:0000269|PubMed:12920247}. Note=Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma. |
| Mouse PG classification | NA |
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