| Gene Information | |
|---|---|
| Gene Name | TRIM27 |
| Organism | Homo sapiens (Human) |
| Gene Length | 513 |
| Protein Names | Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (RING-type E3 ubiquitin transferase TRIM27) (Ret finger protein) (Tripartite motif-containing protein 27) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000204713 ) 3 ( ENSG00000215641 ) 3 ( ENSG00000229006 ) 3 ( ENSG00000233948 ) 3 ( ENSG00000234495 ) 3 ( ENSG00000237071 ) 3 ( ENSG00000237462 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P14373 |
| Gene Card | TRIM27 |
| Uniprot ID | P14373 |
| Pfam | PF13765; PF00622; PF00643 |
| In ASD | no |
| Allosteric Prediction | no (-0.281092663) |
| Ortholog in Animals | Alpaca_ TRIM27 ( ortholog_one2one ) Dog_ TRIM27 ( ortholog_one2one ) GuineaPig_ TRIM27 ( ortholog_one2one ) Macaque_ TRIM27 ( ortholog_one2one ) Mouse_ Trim27 ( ortholog_one2one ) Pig_ TRIM27 ( ortholog_one2one ) Rat_ Trim27 ( ortholog_one2one ) Rabbit_ TRIM27 ( ortholog_one2one ) |
| Ohnologs | TRIM73 |
| Paralogs | TRIM42, TRIM13, TRIM31, TRIM49B, TRIM49C, TRIM49, TRIM33, TRIM69, TRIM71, TRIM77, TRIM28, TRIM3, TRIM46, TRIM58, TRIM38, TRIM5, TRIM37, MID1, TRIM7, TRIM36, TRIM44, TRIML2, TRIM2, TRIM63, TRIM73, TRIM74, TRIM65, TRIML1, MID2, TRIM32, TRIM14, TRIM34, TRIM54, TRIM55, TRIM52, TRIM41, TRIM11, PML, TRIM43, TRIM43B, TRIM21, TRIM6, TRIM40, TRIM51G, TRIM51, TRIM9, TRIM67, TRIM25, TRIM49D1, TRIM48, TRIM49D2, TRIM68, TRIM17, TRIM24, TRIM64C, TRIM64, TRIM64B, TRIM60, TRIM61, TRIM4, TRIM10, BSPRY, TRIM56, TRIM29, TRIM8, MEFV, TRIM15, TRIM22, TRIM35, TRIM16, TRIM47, TRIM45, TRIM72, TRIM62, TRIM50, TRIM75, TRIM66, RNF39, TRIM26, TRIM39 |
| Tissue | NA |
| Tissue Specificity | Expressed in testis namely within the seminiferous tubules. {ECO:0000269|PubMed:12445133}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17156811}. Cytoplasm {ECO:0000269|PubMed:17156811}. Nucleus, PML body {ECO:0000250}. Early endosome {ECO:0000269|PubMed:1437549, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:9247190}. Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). {ECO:0000250, ECO:0000269|PubMed:23452853}. |
| Mouse PG classification | NA |
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