| Gene Information | |
|---|---|
| Gene Name | MAG |
| Organism | Homo sapiens (Human) |
| Gene Length | 626 |
| Protein Names | Myelin-associated glycoprotein (Siglec-4a) |
| Target Name | myelin-associated glycoprotein |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000105695 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P20916 |
| Gene Card | MAG |
| Uniprot ID | P20916 |
| Pfam | PF08205 |
| In ASD | no |
| Allosteric Prediction | no (-0.195615664) |
| Ortholog in Animals | Alpaca_ MAG ( ortholog_one2one ) GuineaPig_ MAG ( ortholog_one2one ) Mouse_ Mag ( ortholog_one2one ) Pig_ MAG ( ortholog_one2one ) Rat_ Mag ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SIGLEC5, TMEM25, SIGLEC1, SIGLEC15, SIGLEC7, SIGLEC11, SIGLEC8, CD33, SIGLEC9, SIGLEC12, SIGLEC16, SIGLEC10, SIGLEC14, SIGLEC6, SIGLECL1, CD22 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures (PubMed:9495552, PubMed:6200494). Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths (PubMed:6200494). Detected in compact myelin (at protein level) (PubMed:6200494). Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system (PubMed:9495552). {ECO:0000269|PubMed:6200494, ECO:0000269|PubMed:9495552}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs762045079 rs2301600 rs11084810 rs587777229 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:26179919}; Single-pass type I membrane protein {ECO:0000269|PubMed:26179919}. Membrane raft {ECO:0000250|UniProtKB:P07722}. |
| Mouse PG classification | LPG |
| click here to return to the previous page | |