| Gene Information | |
|---|---|
| Gene Name | MAEL |
| Organism | Homo sapiens (Human) |
| Gene Length | 434 |
| Protein Names | Protein maelstrom homolog |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000143194 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96JY0 |
| Gene Card | MAEL |
| Uniprot ID | Q96JY0 |
| Pfam | PF09011; PF13017 |
| In ASD | no |
| Allosteric Prediction | no (-0.899657373) |
| Ortholog in Animals | Alpaca_ MAEL ( ortholog_one2one ) Dog_ MAEL ( ortholog_one2one ) GuineaPig_ MAEL ( ortholog_one2one ) Macaque_ MAEL ( ortholog_one2one ) Mouse_ Mael ( ortholog_one2one ) Pig_ MAEL ( ortholog_one2one ) Rat_ Mael ( ortholog_one2one ) Rabbit_ MAEL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | testis |
| Tissue Specificity | Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter. {ECO:0000269|PubMed:19693694, ECO:0000269|Ref.1}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CTO (NMR - ) |
| DBSNP | rs11578336 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q8BVN9}. Nucleus {ECO:0000250|UniProtKB:Q8BVN9}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity). {ECO:0000250|UniProtKB:Q8BVN9}. |
| Mouse PG classification | NA |
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