| Gene Information | |
|---|---|
| Gene Name | MAEA |
| Organism | Homo sapiens (Human) |
| Gene Length | 396 |
| Protein Names | E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP) |
| Target Name | macrophage erythroblast attacher |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000090316 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7L5Y9 |
| Gene Card | MAEA |
| Uniprot ID | Q7L5Y9 |
| Pfam | PF10607 |
| In ASD | no |
| Allosteric Prediction | no (-0.50070328) |
| Ortholog in Animals | Alpaca_ MAEA ( ortholog_one2one ) GuineaPig_ MAEA ( ortholog_one2one ) Macaque_ MAEA ( ortholog_one2one ) Mouse_ Maea ( ortholog_one2one ) Pig_ MAEA ( ortholog_one2one ) Rat_ Maea ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RMND5A, RMND5B |
| Tissue | NA |
| Tissue Specificity | Detected at macrophage membranes (at protein level). Ubiquitous. {ECO:0000269|PubMed:9763581}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.136129(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34082974 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q4VC33}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:24143168, ECO:0000269|PubMed:29911972}. Nucleus matrix {ECO:0000269|PubMed:16510120}. Cell membrane {ECO:0000269|PubMed:9763581}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16510120}. Note=Detected in a nuclear, speckled-like pattern (PubMed:16510120). Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis (PubMed:16510120). Present in cytoplasm, nuclear matrix and at the cell surface in macrophages; predominantly nuclear in immature macrophages and predominantly detected at the cell surface in mature macrophages. Colocalizes with F-actin in macrophages (By similarity). {ECO:0000250|UniProtKB:Q4VC33, ECO:0000269|PubMed:16510120}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |