| Gene Information | |
|---|---|
| Gene Name | MADD |
| Organism | Homo sapiens (Human) |
| Gene Length | 1647 |
| Protein Names | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000110514 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8WXG6 |
| Gene Card | MADD |
| Uniprot ID | Q8WXG6 |
| Pfam | PF02141; PF03456 |
| In ASD | no |
| Allosteric Prediction | no (-0.174467244) |
| Ortholog in Animals | Alpaca_ MADD ( ortholog_one2one ) Dog_ MADD ( ortholog_one2one ) GuineaPig_ MADD ( ortholog_one2one ) Macaque_ MADD ( ortholog_one2one ) Mouse_ Madd ( ortholog_one2one ) Pig_ MADD ( ortholog_one2one ) Rat_ Madd ( ortholog_one2one ) Rabbit_ MADD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in testis, ovary, brain and heart (PubMed:8988362). Expressed in spleen, thymus, prostate, testis, ovary, small instestine and colon (PubMed:9115275). Expressed in liver (PubMed:9796103). {ECO:0000269|PubMed:8988362, ECO:0000269|PubMed:9115275, ECO:0000269|PubMed:9796103}.; [Isoform 1]: Not detected in the brain, breast, kidney, lung, ovary, pancreas, testis, uterus, stomach and thyroid. {ECO:0000269|PubMed:14716293}.; [Isoform 2]: Expressed in the brain, breast, kidney, lung, ovary, pancreas, testis, uterus, stomach and thyroid. {ECO:0000269|PubMed:14716293}.; [Isoform 3]: Expressed in the brain, breast, kidney, lung, ovary, pancreas, testis, uterus, stomach and thyroid. {ECO:0000269|PubMed:14716293}.; [Isoform 4]: Expressed in the brain, breast, kidney, lung, ovary, pancreas, testis, uterus, stomach and thyroid. {ECO:0000269|PubMed:14716293}.; [Isoform 5]: Expressed in the brain, breast, kidney, lung, ovary, pancreas, testis, uterus, stomach and thyroid. {ECO:0000269|PubMed:14716293}.; [Isoform 6]: Not detected in the brain, breast, kidney, lung, ovary, pancreas, testis, uterus, stomach and thyroid. {ECO:0000269|PubMed:14716293}.; [Isoform 7]: Not detected in the brain, breast, kidney, lung, ovary, pancreas, testis, uterus, stomach and thyroid. {ECO:0000269|PubMed:14716293}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs149316791 rs147179561 rs1591767154 rs370382902 rs147713337 rs17854007 rs1051006 rs3736101 rs17854008 rs17854009 rs34534575 rs971864929 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:8988362}. Cytoplasm {ECO:0000269|PubMed:8988362}. Cell projection, axon {ECO:0000250|UniProtKB:Q80U28}. |
| Mouse PG classification | NA |
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