| Gene Information | |
|---|---|
| Gene Name | MAD2L2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 211 |
| Protein Names | Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) (REV7 homolog) (hREV7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000116670 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UI95 |
| Gene Card | MAD2L2 |
| Uniprot ID | Q9UI95 |
| Pfam | PF02301 |
| In ASD | no |
| Allosteric Prediction | no (-0.999974715) |
| Ortholog in Animals | Alpaca_ MAD2L2 ( ortholog_one2one ) Dog_ MAD2L2 ( ortholog_one2one ) GuineaPig_ MAD2L2 ( ortholog_one2one ) Macaque_ MAD2L2 ( ortholog_one2one ) Mouse_ Mad2l2 ( ortholog_one2one ) Pig_ MAD2L2 ( ortholog_one2one ) Rat_ Mad2l2 ( ortholog_one2one ) Rabbit_ MAD2L2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MAD2L1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:11717438}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001531(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3ABD (X-ray 1.90A ) 3ABE (X-ray 2.60A ) 3VU7 (X-ray 2.80A ) 4EXT (X-ray 1.90A ) 4GK0 (X-ray 2.70A ) 4GK5 (X-ray 3.21A ) 5XPT (X-ray 2.10A ) 5XPU (X-ray 2.30A ) 6BC8 (X-ray 1.68A ) 6BCD (X-ray 1.43A ) 6BI7 (X-ray 2.80A ) 6K07 (X-ray 2.24A ) 6K08 (X-ray 2.31A ) 6KEA (X-ray 2.35A ) 6KTO (X-ray 3.45A ) 6M7A (X-ray 1.90A ) 6M7B (X-ray 1.77A ) 6NIF (X-ray 2.00A ) 6VE5 (X-ray 2.00A ) 6WS0 (X-ray 2.24A ) 6WS5 (X-ray 2.47A ) 6WW9 (X-ray 2.70A ) 6WWA (X-ray 3.80A ) 7L9P (EM 3.60A ) |
| DBSNP | rs1057517674 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11717438, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:17719540, ECO:0000269|PubMed:19753112}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19753112, ECO:0000269|PubMed:21063390}. Cytoplasm {ECO:0000269|PubMed:11717438, ECO:0000269|PubMed:17719540}. Chromosome {ECO:0000269|PubMed:29656893}. Note=Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle. {ECO:0000269|PubMed:29656893}. |
| Mouse PG classification | NA |
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