| Gene Information | |
|---|---|
| Gene Name | MAD1L1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 718 |
| Protein Names | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000002822 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y6D9 |
| Gene Card | MAD1L1 |
| Uniprot ID | Q9Y6D9 |
| Pfam | PF05557 |
| In ASD | no |
| Allosteric Prediction | no (-0.403963993) |
| Ortholog in Animals | Alpaca_ MAD1L1 ( ortholog_one2one ) Dog_ MAD1L1 ( ortholog_one2one ) GuineaPig_ MAD1L1 ( ortholog_one2one ) Macaque_ MAD1L1 ( ortholog_one2one ) Mouse_ Mad1l1 ( ortholog_one2one ) Pig_ MAD1L1 ( ortholog_one2one ) Rat_ Mad1l1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Expressed in hepatocellular carcinomas and hepatoma cell lines (at protein level). {ECO:0000269|PubMed:19010891, ECO:0000269|PubMed:24374861}.; [Isoform 3]: Expressed in hepatocellular carcinomas and hepatoma cell lines (at protein level). {ECO:0000269|PubMed:19010891}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1GO4 (X-ray 2.05A ) 4DZO (X-ray 1.76A ) 7B1F (X-ray 1.75A ) 7B1H (X-ray 2.40A ) 7B1J (X-ray 2.90A ) |
| DBSNP | rs121908982 rs550573452 rs769418574 rs193231481 rs377555260 rs371561369 rs755012008 rs1801368 rs201951163 rs1801500 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19010891, ECO:0000269|PubMed:9546394}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:29162720}. Nucleus envelope {ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:22351768}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:9546394}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9546394}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:22351768}. Note=Co-localizes with TPR at the nucleus envelope during interphase and throughout the cell cycle (PubMed:22351768, PubMed:18981471). From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody (PubMed:9546394). Localizes to kinetochores during prometaphase (PubMed:22351768, PubMed:29162720). Does not localize to kinetochores during metaphase (PubMed:29162720). Colocalizes with NEK2 at the kinetochore (PubMed:14978040). Colocalizes with IK at spindle poles during metaphase and anaphase (PubMed:22351768). {ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:9546394}.; [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:19010891}. |
| Mouse PG classification | NA |
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