| Gene Information | |
|---|---|
| Gene Name | MACROH2A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 372 |
| Protein Names | Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000099284 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9P0M6 |
| Gene Card | MACROH2A2 |
| Uniprot ID | Q9P0M6 |
| Pfam | PF00125; PF16211; PF01661 |
| In ASD | no |
| Allosteric Prediction | no (-0.595642094) |
| Ortholog in Animals | Alpaca_ MACROH2A2 ( ortholog_one2one ) Dog_ MACROH2A2 ( ortholog_one2one ) GuineaPig_ MACROH2A2 ( ortholog_one2one ) Macaque_ MACROH2A2 ( ortholog_one2one ) Mouse_ Macroh2a2 ( ortholog_one2one ) Pig_ MACROH2A2 ( ortholog_one2one ) Rat_ Macroh2a2 ( ortholog_one2one ) Rabbit_ MACROH2A2 ( ortholog_one2one ) |
| Ohnologs | MACROH2A1 |
| Paralogs | H2AC1, H2AC19, H2AC18, H2AL1Q, H2AL3, H2AB1, H2AB3, H2AB2, H2AC7, MACROH2A1, H2AZ1, H2AZ2, H2AJ, H2AC20, H2AC21, H2AC6, H2AC4, H2AC8, H2AW, H2AC15, H2AC13, H2AC17, H2AC11, H2AC16, H2AC12, H2AC14, H2AX |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2XD7 (X-ray 2.09A ) 6FY5 (X-ray 1.65A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11262398, ECO:0000269|PubMed:11331621, ECO:0000269|PubMed:15621527}. Chromosome {ECO:0000269|PubMed:11262398, ECO:0000269|PubMed:11331621, ECO:0000269|PubMed:15621527}. Note=Enriched in inactive X chromosome chromatin (PubMed:11331621, PubMed:11262398) and in senescence-associated heterochromatin (PubMed:15621527). {ECO:0000269|PubMed:11262398, ECO:0000269|PubMed:11331621, ECO:0000269|PubMed:15621527}. |
| Mouse PG classification | NA |
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