| Gene Information | |
|---|---|
| Gene Name | MACROH2A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 369 |
| Protein Names | Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000113648 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75367 |
| Gene Card | MACROH2A1 |
| Uniprot ID | O75367 |
| Pfam | PF00125; PF16211; PF01661 |
| In ASD | no |
| Allosteric Prediction | no (-0.298375514) |
| Ortholog in Animals | Alpaca_ MACROH2A1 ( ortholog_one2one ) Dog_ MACROH2A1 ( ortholog_one2one ) GuineaPig_ MACROH2A1 ( ortholog_one2one ) Macaque_ MACROH2A1 ( ortholog_one2one ) Mouse_ Macroh2a1 ( ortholog_one2one ) Pig_ MACROH2A1 ( ortholog_one2one ) Rat_ Macroh2a1 ( ortholog_one2one ) Rabbit_ MACROH2A1 ( ortholog_one2one ) |
| Ohnologs | MACROH2A2 |
| Paralogs | H2AC1, H2AC19, H2AC18, H2AL1Q, H2AL3, H2AB1, H2AB3, H2AB2, H2AC7, H2AZ1, H2AZ2, H2AJ, H2AC20, H2AC21, H2AC6, H2AC4, H2AC8, H2AW, MACROH2A2, H2AC15, H2AC13, H2AC17, H2AC11, H2AC16, H2AC12, H2AC14, H2AX |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:9714746}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001293(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1U35 (X-ray 3.00A ) 1ZR3 (X-ray 1.66A ) 1ZR5 (X-ray 2.92A ) 2F8N (X-ray 2.90A ) 2FXK (X-ray 2.54A ) 3HQH (X-ray 2.30A ) 3HSV (X-ray 1.43A ) 3IID (X-ray 1.90A ) 3IIF (X-ray 2.10A ) 3IVB (X-ray 1.75A ) 5IIT (X-ray 2.13A ) 5LNC (X-ray 3.29A ) 7D3Y (X-ray 3.11A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:9634239}. Chromosome {ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:29905837, ECO:0000269|PubMed:9634239}. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin (PubMed:15621527, PubMed:15897469, PubMed:9634239). Recruited to DNA damage sites in an APLF-dependent manner (PubMed:21211722, PubMed:29905837). {ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:21211722, ECO:0000269|PubMed:29905837, ECO:0000269|PubMed:9634239}. |
| Mouse PG classification | NA |
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