| Gene Information | |
|---|---|
| Gene Name | MACROD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 325 |
| Protein Names | ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000133315 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9BQ69 |
| Gene Card | MACROD1 |
| Uniprot ID | Q9BQ69 |
| Pfam | PF01661 |
| In ASD | no |
| Allosteric Prediction | yes (0.086296169) |
| Ortholog in Animals | Alpaca_ MACROD1 ( ortholog_one2one ) Dog_ MACROD1 ( ortholog_one2one ) GuineaPig_ MACROD1 ( ortholog_one2one ) Macaque_ MACROD1 ( ortholog_one2one ) Mouse_ Macrod1 ( ortholog_one2one ) Pig_ MACROD1 ( ortholog_one2one ) Rat_ Macrod1 ( ortholog_one2one ) |
| Ohnologs | MACROD2 |
| Paralogs | GDAP2, MACROD2 |
| Tissue | artery, heart, left.atrium, left.ventricle, penis, tongue |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2X47 (X-ray 1.70A ) 6LH4 (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:23474712}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. {ECO:0000269|PubMed:23474712}. |
| Mouse PG classification | NA |
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