Gene Information
Gene NameLZIP
OrganismHomo sapiens (Human)
Gene Length371
Protein NamesCyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)]
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBO43889
Gene CardCREB3
Uniprot IDO43889
PfamPF00170
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityUbiquitously expressed (PubMed:9271389, PubMed:19779205). Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level) (PubMed:20546900). {ECO:0000269|PubMed:19779205, ECO:0000269|PubMed:20546900, ECO:0000269|PubMed:9271389}.
Pharmacological Animal Models0.029547(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC][Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10623756, ECO:0000269|PubMed:12138176, ECO:0000269|PubMed:18391022};
Single-pass type II membrane protein {ECO:0000255, ECO:0000269|PubMed:12138176}. Golgi apparatus {ECO:0000269|PubMed:10623756}. Note=Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (PubMed:10623756). Colocalizes with DCSTAMP in the ER membrane of immature dendritic cell (DC) (PubMed:20546900). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane (PubMed:10623756). {ECO:0000269|PubMed:10623756, ECO:0000269|PubMed:20546900}.;
[Isoform 1]: Cytoplasm. Note=(Microbial infection) Sequestered into the cytoplasm by the HCV core protein. {ECO:0000269|PubMed:10675342}.;
[Isoform 2]: Nucleus {ECO:0000269|PubMed:19779205}. Cytoplasm {ECO:0000269|PubMed:19779205}. Note=Predominantly in the nucleus (PubMed:19779205). Not associated with membranes (PubMed:19779205). {ECO:0000269|PubMed:19779205}.;
[Processed cyclic AMP-responsive element-binding protein 3]: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB). {ECO:0000269|PubMed:10675342, ECO:0000269|PubMed:15705566, ECO:0000269|PubMed:18391022, ECO:0000269|PubMed:20546900}.
Mouse PG classificationNA
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