| Gene Information | |
|---|---|
| Gene Name | LYZL3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 215 |
| Protein Names | Sperm acrosome membrane-associated protein 3 (Cancer/testis antigen 54) (CT54) (Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17) (Lysozyme-like protein 3) (Sperm lysozyme-like protein 1) (Sperm protein reactive with antisperm antibodies) (Sperm protein reactive with ASA) [Cleaved into: Sperm acrosome membrane-associated protein 3, membrane form; Sperm acrosome membrane-associated protein 3, processed form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8IXA5 |
| Gene Card | SPACA3 |
| Uniprot ID | Q8IXA5 |
| Pfam | PF00062 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | The processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and placenta. {ECO:0000269|PubMed:12606493, ECO:0000269|PubMed:16014814}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16967845 rs28963 rs35420663 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction. {ECO:0000250}.; [Isoform 2]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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