| Gene Information | |
|---|---|
| Gene Name | LYVE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 322 |
| Protein Names | Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1) (Hyaluronic acid receptor) |
| Target Name | hyaluronic acid receptor |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000133800 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9Y5Y7 |
| Gene Card | LYVE1 |
| Uniprot ID | Q9Y5Y7 |
| Pfam | PF00193 |
| In ASD | no |
| Allosteric Prediction | no (-0.46650607) |
| Ortholog in Animals | Alpaca_ LYVE1 ( ortholog_one2one ) Dog_ LYVE1 ( ortholog_one2one ) GuineaPig_ LYVE1 ( ortholog_one2one ) Macaque_ LYVE1 ( ortholog_one2one ) Mouse_ Lyve1 ( ortholog_one2one ) Pig_ LYVE1 ( ortholog_one2one ) Rabbit_ LYVE1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CD44 |
| Tissue | NA |
| Tissue Specificity | Mainly expressed in endothelial cells lining lymphatic vessels. {ECO:0000269|PubMed:10037799, ECO:0000269|PubMed:26823460}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17852369 rs16907980 rs7948666 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10037799, ECO:0000269|PubMed:26823460}; Single-pass type I membrane protein {ECO:0000269|PubMed:10037799}. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. Localizes at cell-cell junctions. |
| Mouse PG classification | NA |
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