Gene Information
Gene NameSLC47A2
OrganismHomo sapiens (Human)
Gene Length602
Protein NamesMultidrug and toxin extrusion protein 2 (MATE-2) (hMATE-2) (Kidney-specific H(+)/organic cation antiporter) (Solute carrier family 47 member 2)
Target Namemultidrug and toxin extrusion protein 2
Target TypeLiterature-reported target
Gene Age645 ( ENSG00000180638 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ86VL8
Gene CardSLC47A2
Uniprot IDQ86VL8
PfamPF01554
In ASDno
Allosteric Predictionno (-0.449609167)
Ortholog in AnimalsAlpaca_ SLC47A2 ( ortholog_one2one )
Dog_ SLC47A2 ( ortholog_one2one )
Macaque_ SLC47A2 ( ortholog_one2one )
Pig_ SLC47A2 ( ortholog_one2one )
Rabbit_ SLC47A2 ( ortholog_one2one )
OhnologsNA
ParalogsSLC47A1
Tissuekidney, medulla.oblongata
Tissue Specificity[Isoform 1]: High expression in kidney. Very small expression in adrenal gland and lung. {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:21419862}.;
[Isoform 3]: High expression in kidney. Very small expression in brain and testis. {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:21419862}.;
[Isoform 6]: Ubiquitously expressed in all tissues examined except the kidney. {ECO:0000269|PubMed:16807400}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs34399035 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:19158817};
Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:21419862};
Multi-pass membrane protein {ECO:0000255}. Note=Detected in the renal urinary tubules. {ECO:0000269|PubMed:21419862}.;
[Isoform 6]: Apical cell membrane {ECO:0000269|PubMed:16807400};
Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of the proximal tubules. {ECO:0000269|PubMed:16807400}.
Mouse PG classificationNA
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