| Gene Information | |
|---|---|
| Gene Name | LYPLA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 412 |
| Protein Names | Phospholipase A2 group XV (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A and acyltransferase) (EC 2.3.1.-, EC 3.1.1.32, EC 3.1.1.4) (Lysosomal phospholipase A2) (LPLA2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8NCC3 |
| Gene Card | PLA2G15 |
| Uniprot ID | Q8NCC3 |
| Pfam | PF02450 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in blood plasma (at protein level) (PubMed:10092508, PubMed:20410020). Ubiquitous. Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes (PubMed:10092508). {ECO:0000269|PubMed:10092508, ECO:0000269|PubMed:20410020}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.08(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4X90 (X-ray 1.84A ) 4X91 (X-ray 2.30A ) 4X92 (X-ray 3.00A ) 4X93 (X-ray 2.60A ) 4X94 (X-ray 2.70A ) 4X95 (X-ray 3.08A ) 4X97 (X-ray 2.65A ) 6MTW (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Lysosome {ECO:0000269|PubMed:23958596}. Secreted {ECO:0000269|PubMed:10092508, ECO:0000269|PubMed:20410020}. Membrane {ECO:0000269|PubMed:25727495}; Peripheral membrane protein {ECO:0000269|PubMed:25727495}. |
| Mouse PG classification | NA |
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