| Gene Information | |
|---|---|
| Gene Name | LILRA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 483 |
| Protein Names | Leukocyte immunoglobulin-like receptor subfamily A member 2 (CD85 antigen-like family member H) (Immunoglobulin-like transcript 1) (ILT-1) (Leukocyte immunoglobulin-like receptor 7) (LIR-7) (CD antigen CD85h) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000239998 ) 3 ( ENSG00000274000 ) 3 ( ENSG00000275290 ) 3 ( ENSG00000278634 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q8N149 |
| Gene Card | LILRA2 |
| Uniprot ID | Q8N149 |
| Pfam | PF00047; PF13895 |
| In ASD | no |
| Allosteric Prediction | no (-1.027352367) |
| Ortholog in Animals | Alpaca_ LILRA2 ( ortholog_one2many ) Macaque_ LILRAB ( ortholog_many2many ) Mouse_ Pira1 ( ortholog_many2many ) Mouse_ Lilra6 ( ortholog_many2many ) Mouse_ Pira12 ( ortholog_many2many ) Mouse_ Pira2 ( ortholog_many2many ) Mouse_ Pira13 ( ortholog_many2many ) Mouse_ Lilra5 ( ortholog_many2many ) Mouse_ Pirb ( ortholog_many2many ) Rat_ Lilrb2 ( ortholog_many2many ) Rat_ Lilra5 ( ortholog_many2many ) Rat_ Lilrc2 ( ortholog_many2many ) Rat_ Lilrb1 ( ortholog_many2many ) Rat_ Lilrb3 ( ortholog_many2many ) Rat_ Lilrb3a ( ortholog_many2many ) Rat_ Lilrb3l ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | LILRB2, LILRB1, LILRA1, LILRB5, LILRA4, LILRA6, LILRA5, LILRB4, LILRB3, NCR1, KIR2DL3, KIR3DL3, KIR3DL2, KIR3DL1, KIR2DS4, KIR2DL4, FCAR, KIR2DL1, GP6, IGSF1, OSCAR, TARM1, VSTM1, LAIR2, A1BG |
| Tissue | bone.marrow, spleen, appendix, whole.blood |
| Tissue Specificity | Detected on the surface of all peripheral blood monocytes, neutrophils, basophils and eosinophils (at protein level) (PubMed:12529506, PubMed:22479404). Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cells and natural killer (NK) cells (PubMed:9548455). {ECO:0000269|PubMed:12529506, ECO:0000269|PubMed:22479404, ECO:0000269|PubMed:9548455}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2OTP (X-ray 2.60A ) |
| DBSNP | rs1834697 rs1834698 rs7249811 rs7249154 rs7249054 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12529506, ECO:0000269|PubMed:22479404, ECO:0000269|PubMed:27572839}; Single-pass type I membrane protein {ECO:0000305|PubMed:12529506, ECO:0000305|PubMed:22479404}.; [Isoform 4]: Secreted {ECO:0000303|PubMed:19658091}. |
| Mouse PG classification | NA |
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