| Gene Information | |
|---|---|
| Gene Name | LYN |
| Organism | Homo sapiens (Human) |
| Gene Length | 512 |
| Protein Names | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) |
| Target Name | tyrosine-protein kinase lyn |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000254087 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P07948 |
| Gene Card | LYN |
| Uniprot ID | P07948 |
| Pfam | PF07714; PF00017; PF00018 |
| In ASD | yes |
| Allosteric Prediction | yes (1.335990547) |
| Ortholog in Animals | Alpaca_ LYN ( ortholog_one2one ) Dog_ LYN ( ortholog_one2one ) GuineaPig_ LYN ( ortholog_one2one ) Macaque_ LYN ( ortholog_one2one ) Mouse_ Lyn ( ortholog_one2one ) Pig_ LYN ( ortholog_one2one ) Rat_ Lyn ( ortholog_one2one ) Rabbit_ LYN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Detected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung, liver and kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors. {ECO:0000269|PubMed:3561390, ECO:0000269|PubMed:8064233}. |
| Pharmacological Animal Models | 0.006213(Chimpanzee);0.012931(Mouse);0.001186(Rat);0.012245(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1W1F (NMR - ) 1WA7 (NMR - ) 3A4O (X-ray 3.00A ) 5XY1 (X-ray 2.70A ) 6NMW (X-ray 1.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts. |
| Mouse PG classification | NA |
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