| Gene Information | |
|---|---|
| Gene Name | LYAR |
| Organism | Homo sapiens (Human) |
| Gene Length | 379 |
| Protein Names | Cell growth-regulating nucleolar protein |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000145220 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NX58 |
| Gene Card | LYAR |
| Uniprot ID | Q9NX58 |
| Pfam | PF17848; PF08790 |
| In ASD | no |
| Allosteric Prediction | no (-1.437128258) |
| Ortholog in Animals | Alpaca_ LYAR ( ortholog_one2one ) Dog_ LYAR ( ortholog_one2many ) Macaque_ LYAR ( ortholog_one2one ) Mouse_ Lyar ( ortholog_one2one ) Pig_ LYAR ( ortholog_one2one ) Rat_ Lyar ( ortholog_one2one ) Rabbit_ LYAR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in testis. {ECO:0000269|PubMed:24990247}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.023404(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6ZMI (EM 2.60A ) 6ZMO (EM 3.10A ) 6ZVH (EM 2.90A ) |
| DBSNP | rs2272739 rs7376390 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:31413131}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:24495227}. Cytoplasm {ECO:0000269|PubMed:24990247}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q08288}. Note=Component of pre-ribosomal particles, including pre-40S, pre-60S and pre-90S (PubMed:24495227). Associated with cytoplasmic ribosomes, but not polysomes, as a component of the 60S subunit (PubMed:24990247). In the retina, predominantly expressed in photoreceptor outer segments (By similarity). In the nucleolus, colocalizes with nucleolin/NCL, therefore may reside in the dense fibrillar component (DFC) (By similarity). {ECO:0000250|UniProtKB:Q08288, ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:24990247}. |
| Mouse PG classification | NA |
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