Gene Information
Gene NameEPM2A
OrganismHomo sapiens (Human)
Gene Length331
Protein NamesLaforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000112425 )
Evolutionary StageEumetazoa
AlphaFoldDBO95278
Gene CardEPM2A
Uniprot IDO95278
PfamPF00686; PF00782
In ASDno
Allosteric Predictionno (-0.234344599)
Ortholog in AnimalsAlpaca_ EPM2A ( ortholog_one2one )
GuineaPig_ EPM2A ( ortholog_one2one )
Macaque_ EPM2A ( ortholog_one2one )
Mouse_ Epm2a ( ortholog_one2one )
Pig_ EPM2A ( ortholog_one2one )
Rat_ Epm2a ( ortholog_one2one )
OhnologsNA
ParalogsDUSP6, DUSP4, DUSP12, DUSP10, STYXL2, SSH3, DUSP19, DUSP1, KASH5, SSH1, DUSP29, DUSP16, DUSP21, DUSP2, DUSP8, DUSP13, DUSP7, DUSP26, STYX, SSH2, PTPMT1, DUSP22, DUSP18, DUSP15, DUSP14, DUSP28, STYXL1, DUSP5, DUSP9, DUSP3
TissueNA
Tissue SpecificityExpressed in heart, skeletal muscle, kidney, pancreas and brain. Isoform 4 is also expressed in the placenta. {ECO:0000269|PubMed:14532330, ECO:0000269|PubMed:9771710}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002990(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4R30  (X-ray  2.30A  )  4RKK  (X-ray  2.40A  ) 
DBSNP rs104893955  rs374338349  rs1362231306  rs1463000703  rs137852915  rs137852916  rs375544596  rs137852917  rs796052427  rs796052428 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:11220751, ECO:0000269|PubMed:11739371, ECO:0000269|PubMed:15102711, ECO:0000269|PubMed:17908927}. Note=Under glycogenolytic conditions localizes to the nucleus. {ECO:0000269|PubMed:17908927}.;
[Isoform 1]: Cytoplasm {ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:11739371, ECO:0000269|PubMed:11883934, ECO:0000269|PubMed:14532330, ECO:0000269|PubMed:18311786, ECO:0000269|PubMed:18617530, ECO:0000269|PubMed:22036712}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:14722920, ECO:0000269|PubMed:18311786};
Peripheral membrane protein {ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:18311786};
Cytoplasmic side {ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:18311786}. Cell membrane {ECO:0000269|PubMed:11220751}. Note=Colocalizes with glycogen synthase in punctate structures in the cytoplasm (PubMed:11739371, PubMed:14532330). Primarily associated with polyribosomes at the rough endoplasmic reticulum, and also detected at the plasma membrane (PubMed:11001928, PubMed:11220751, PubMed:11883934, PubMed:18311786). {ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:11220751, ECO:0000269|PubMed:11739371, ECO:0000269|PubMed:11883934, ECO:0000269|PubMed:14532330, ECO:0000269|PubMed:18311786}.;
[Isoform 2]: Cytoplasm {ECO:0000269|PubMed:18617530}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11883934};
Peripheral membrane protein {ECO:0000269|PubMed:11883934};
Cytoplasmic side {ECO:0000269|PubMed:11883934}. Cell membrane {ECO:0000269|PubMed:11883934}. Nucleus {ECO:0000269|PubMed:11883934, ECO:0000269|PubMed:14722920, ECO:0000269|PubMed:18617530}. Note=Also found in the nucleus. {ECO:0000269|PubMed:11883934, ECO:0000269|PubMed:18617530}.;
[Isoform 4]: Cytoplasm {ECO:0000269|PubMed:22036712}. Nucleus {ECO:0000269|PubMed:22036712}.;
[Isoform 5]: Cytoplasm {ECO:0000269|PubMed:22036712}. Nucleus {ECO:0000269|PubMed:22036712}.;
[Isoform 7]: Cytoplasm {ECO:0000269|PubMed:22036712}.
Mouse PG classificationHPG
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