| Gene Information | |
|---|---|
| Gene Name | LTRPC4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1214 |
| Protein Names | Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8TD43 |
| Gene Card | TRPM4 |
| Uniprot ID | Q8TD43 |
| Pfam | PF00520; PF18139 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells. Expressed in keratocytes (PubMed:30528822). {ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367, ECO:0000269|PubMed:15472118, ECO:0000269|PubMed:16777713, ECO:0000269|PubMed:19726882, ECO:0000269|PubMed:20656926, ECO:0000269|PubMed:30528822}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5WP6 (EM 3.80A ) 6BQR (EM 3.20A ) 6BQV (EM 3.10A ) 6BWI (EM 3.70A ) |
| DBSNP | rs267607142 rs113984787 rs144781529 rs172146854 rs387907216 rs146564314 rs172147855 rs201907325 rs56355369 rs172149856 rs172150857 rs200038418 rs172155862 rs172151858 rs172152859 rs1278993777 rs1369949906 rs150391806 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:15331675, ECO:0000269|PubMed:15590641, ECO:0000269|PubMed:19945433, ECO:0000269|PubMed:29211723}; Multi-pass membrane protein {ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581}. Endoplasmic reticulum {ECO:0000269|PubMed:19945433}. Golgi apparatus {ECO:0000269|PubMed:19945433}.; [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11535825}. Endoplasmic reticulum. Golgi apparatus. |
| Mouse PG classification | NA |
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