| Gene Information | |
|---|---|
| Gene Name | LTRPC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1732 |
| Protein Names | Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9HCF6 |
| Gene Card | TRPM3 |
| Uniprot ID | Q9HCF6 |
| Pfam | PF00520; PF18139; PF16519 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. {ECO:0000269|PubMed:12672799, ECO:0000269|PubMed:12672827}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs13440436 rs6560142 rs41287373 rs17535963 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12672827, ECO:0000305|PubMed:21278253}; Multi-pass membrane protein {ECO:0000269|PubMed:12672827}. |
| Mouse PG classification | NA |
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