| Gene Information | |
|---|---|
| Gene Name | LTRPC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1603 |
| Protein Names | Transient receptor potential cation channel subfamily M member 1 (Long transient receptor potential channel 1) (LTrpC1) (Melastatin-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q7Z4N2 |
| Gene Card | TRPM1 |
| Uniprot ID | Q7Z4N2 |
| Pfam | PF00520; PF18139; PF16519 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in the retina where it localizes to the outer plexiform layer. Specifically, it is expressed in retinal bipolar cells (BPCs) of the ON subtype (PubMed:30027108). Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing. {ECO:0000269|PubMed:11112417, ECO:0000269|PubMed:19896109, ECO:0000269|PubMed:30027108, ECO:0000269|PubMed:9537257}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2241493 rs200514769 rs774365264 rs191205969 rs372608320 rs141540242 rs748043795 rs1261040173 rs17815774 rs267607139 rs781460164 rs574652148 rs369484186 rs182549235 rs17227996 rs13380059 rs61734298 rs3784588 rs3784587 rs12898290 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21278253}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:11535825}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30027108}; Multi-pass membrane protein {ECO:0000269|PubMed:30027108}. Cell projection, axon {ECO:0000250|UniProtKB:Q2TV84}. |
| Mouse PG classification | NA |
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