| Gene Information | |
|---|---|
| Gene Name | LTK |
| Organism | Homo sapiens (Human) |
| Gene Length | 864 |
| Protein Names | Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1) |
| Target Name | leukocyte tyrosine kinase receptor |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000062524 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P29376 |
| Gene Card | LTK |
| Uniprot ID | P29376 |
| Pfam | PF07714 |
| In ASD | no |
| Allosteric Prediction | yes (0.015873365) |
| Ortholog in Animals | Alpaca_ LTK ( ortholog_one2one ) Macaque_ LTK ( ortholog_one2one ) Mouse_ Ltk ( ortholog_one2one ) Rat_ Ltk ( ortholog_one2one ) Rabbit_ LTK ( ortholog_one2one ) |
| Ohnologs | ALK |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Expressed in non-hematopoietic cell lines and T- and B-cell lines. {ECO:0000269|PubMed:2156206}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7NX0 (X-ray 1.95A ) 7NX1 (X-ray 1.30A ) |
| DBSNP | rs2305030 rs55683312 rs35932273 rs148513655 rs55876255 rs55900837 rs76282169 rs56367146 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:34646012}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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