Gene Information
Gene NameLTF
OrganismHomo sapiens (Human)
Gene Length710
Protein NamesLactotransferrin (Lactoferrin) (EC 3.4.21.-) (Growth-inhibiting protein 12) (Talalactoferrin) [Cleaved into: Lactoferricin-H (Lfcin-H); Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C]
Target Namelactotransferrin
Target TypeClinical trial target
Gene Age645 ( ENSG00000012223 )
Evolutionary StageEumetazoa
AlphaFoldDBP02788
Gene CardLTF
Uniprot IDP02788
PfamPF00405
In ASDno
Allosteric Predictionyes (0.702269158)
Ortholog in AnimalsAlpaca_ LTF ( ortholog_one2one )
Dog_ LTF ( ortholog_one2one )
GuineaPig_ LTF ( ortholog_one2one )
Macaque_ LTF ( ortholog_one2one )
Mouse_ Ltf ( ortholog_one2one )
Pig_ LTF ( ortholog_one2one )
Rat_ Ltf ( ortholog_one2one )
Rabbit_ LTF ( ortholog_one2one )
OhnologsMELTF
ParalogsMELTF, TF, SRPRB
Tissueminor.salivary.gland
Tissue SpecificityHigh levels are found in saliva and tears, intermediate levels in serum and plasma, and low levels in urine. In kidney, detected in the distal collecting tubules in the medulla but not in the cortical region or in blood vessels. Detected in peripheral blood neutrophils (at protein level). Isoform 1 and isoform DeltaLf are expressed in breast, prostate, spleen, pancreas, kidney, small intestine, lung, skeletal muscle, uterus, thymus and fetal liver. Isoform 1 is expressed in brain, testis and peripheral blood leukocytes;
isoform DeltaLf is barely detectable in these tissues. Isoform DeltaLf is expressed in placenta, liver and ovary;
isoform 1 is barely detectable in these tissues. In kidney, isoform 1 is expressed at high levels in the collecting tubules of the medulla but at very low levels in the cortex. {ECO:0000269|PubMed:10792619, ECO:0000269|PubMed:2981589, ECO:0000269|PubMed:9122171}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1B0L  (X-ray  2.20A  )  1BKA  (X-ray  2.40A  )  1CB6  (X-ray  2.00A  )  1DSN  (X-ray  2.05A  )  1EH3  (X-ray  2.00A  )  1FCK  (X-ray  2.20A  )  1H43  (X-ray  2.20A  )  1H44  (X-ray  2.00A  )  1H45  (X-ray  1.95A  )  1HSE  (X-ray  2.20A  )  1L5T  (X-ray  3.00A  )  1LCF  (X-ray  2.00A  )  1LCT  (X-ray  2.00A  )  1LFG  (X-ray  2.20A  )  1LFH  (X-ray  2.80A  )  1LFI  (X-ray  2.10A  )  1LGB  (X-ray  3.30A  )  1N76  (X-ray  3.40A  )  1SQY  (X-ray  2.50A  )  1U62  (NMR  -  )  1VFD  (X-ray  2.50A  )  1VFE  (X-ray  2.30A  )  1XV4  (NMR  -  )  1XV7  (NMR  -  )  1Z6V  (NMR  -  )  1Z6W  (NMR  -  )  2BJJ  (X-ray  2.40A  )  2DP4  (X-ray  2.90A  )  2GMC  (NMR  -  )  2GMD  (NMR  -  )  2HD4  (X-ray  2.15A  )  2PMS  (X-ray  2.91A  )  7N88  (EM  3.70A  ) 
DBSNP rs10662431  rs1126477  rs1126478  rs1126479  rs1042055  rs2073495 
Subcellular location [CC][Isoform 1]: Secreted. Cytoplasmic granule. Note=Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils.;
[Isoform DeltaLf]: Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm.
Mouse PG classificationNA
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