Gene Information
Gene NameLTC4S
OrganismHomo sapiens (Human)
Gene Length150
Protein NamesLeukotriene C4 synthase (LTC4 synthase) (EC 4.4.1.20) (Glutathione S-transferase LTC4) (EC 2.5.1.-) (Leukotriene-C(4) synthase) (Leukotriene-C4 synthase)
Target Nameleukotriene c4 synthase
Target TypeNA
Gene Age645 ( ENSG00000213316 )
3 ( ENSG00000283887 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ16873
Gene CardLTC4S
Uniprot IDQ16873
PfamPF01124
In ASDno
Allosteric Predictionyes (0.017908924)
Ortholog in AnimalsAlpaca_ LTC4S ( ortholog_one2one )
Dog_ LTC4S ( ortholog_one2one )
GuineaPig_ LTC4S ( ortholog_one2one )
Macaque_ LTC4S ( ortholog_one2one )
Pig_ LTC4S ( ortholog_one2one )
OhnologsMGST2
ParalogsMGST2, MGST3, ALOX5AP
TissueNA
Tissue SpecificityDetected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets. {ECO:0000269|PubMed:7599836}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2PNO  (X-ray  3.30A  )  2UUH  (X-ray  2.15A  )  2UUI  (X-ray  2.00A  )  3B29  (X-ray  3.20A  )  3HKK  (X-ray  2.90A  )  3LEO  (X-ray  2.10A  )  3PCV  (X-ray  1.90A  )  4BPM  (X-ray  2.08A  )  4J7T  (X-ray  3.20A  )  4J7Y  (X-ray  2.90A  )  4JC7  (X-ray  2.70A  )  4JCZ  (X-ray  2.75A  )  4JRZ  (X-ray  2.40A  )  4WAB  (X-ray  2.70A  )  5HV9  (X-ray  3.00A  )  6R7D  (X-ray  2.35A  ) 
DBSNP rs11541078 
Subcellular location [CC]Nucleus outer membrane {ECO:0000269|PubMed:12023288};
Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12023288, ECO:0000269|PubMed:19233132};
Multi-pass membrane protein. Nucleus membrane {ECO:0000269|PubMed:19233132};
Multi-pass membrane protein.
Mouse PG classificationLPG
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