| Gene Information | |
|---|---|
| Gene Name | LTBP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1303 |
| Protein Names | Latent-transforming growth factor beta-binding protein 3 (LTBP-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000168056 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NS15 |
| Gene Card | LTBP3 |
| Uniprot ID | Q9NS15 |
| Pfam | PF12662; PF07645; PF00683 |
| In ASD | no |
| Allosteric Prediction | no (-1.035746808) |
| Ortholog in Animals | Alpaca_ LTBP3 ( ortholog_one2one ) Dog_ LTBP3 ( ortholog_one2one ) GuineaPig_ LTBP3 ( ortholog_one2one ) Macaque_ LTBP3 ( ortholog_one2one ) Mouse_ Ltbp3 ( ortholog_one2one ) Pig_ LTBP3 ( ortholog_one2one ) Rat_ Ltbp3 ( ortholog_one2one ) |
| Ohnologs | LTBP4, LTBP2, LTBP1 |
| Paralogs | LTBP1, LTBP2, LTBP4 |
| Tissue | NA |
| Tissue Specificity | Isoform 2: Expressed prominently in heart, skeletal muscle, prostate, testis, small intestine and ovary (PubMed:12154076). Isoform 1: Strongly expressed in pancreas and liver (PubMed:12154076). {ECO:0000269|PubMed:12154076}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1554974135 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:12154076}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:16157329}. Note=Secretion occurs after coexpression with TGFB1 and requires complexing with 'Cys-33' of the TGFB1 propeptide. {ECO:0000269|PubMed:12154076}. |
| Mouse PG classification | HPG |
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