| Gene Information | |
|---|---|
| Gene Name | HERC4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1057 |
| Protein Names | Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000148634 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q5GLZ8 |
| Gene Card | HERC4 |
| Uniprot ID | Q5GLZ8 |
| Pfam | PF00632; PF00415 |
| In ASD | no |
| Allosteric Prediction | no (-0.688412066) |
| Ortholog in Animals | Alpaca_ HERC4 ( ortholog_one2one ) Dog_ HERC4 ( ortholog_one2one ) GuineaPig_ HERC4 ( ortholog_one2one ) Macaque_ HERC4 ( ortholog_one2one ) Mouse_ Herc4 ( ortholog_one2one ) Pig_ HERC4 ( ortholog_one2one ) Rat_ Herc4 ( ortholog_one2one ) Rabbit_ HERC4 ( ortholog_one2one ) |
| Ohnologs | HERC3, HERC6, HERC5 |
| Paralogs | NEDD4, HECTD1, NEDD4L, UBE3B, HUWE1, SMURF1, AREL1, UBR5, HERC2, HECW2, HERC3, WWP1, UBE3A, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, ITCH, HECW1, WWP2, TRIP12, HERC5, HERC6 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain and testis and detected in heart and placenta. {ECO:0000269|PubMed:15676274}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:15676274}. Note=shows a punctate cytoplasmic distribution. |
| Mouse PG classification | NA |
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