| Gene Information | |
|---|---|
| Gene Name | LTA |
| Organism | Homo sapiens (Human) |
| Gene Length | 205 |
| Protein Names | Lymphotoxin-alpha (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1) |
| Target Name | lymphotoxin-alpha |
| Target Type | Clinical trial target |
| Gene Age | 3 ( ENSG00000173503 ) 3 ( ENSG00000223919 ) 3 ( ENSG00000226275 ) 454 ( ENSG00000226979 ) 3 ( ENSG00000230279 ) 3 ( ENSG00000231408 ) 3 ( ENSG00000238130 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P01374 |
| Gene Card | LTA |
| Uniprot ID | P01374 |
| Pfam | PF00229 |
| In ASD | no |
| Allosteric Prediction | no (-0.009258122) |
| Ortholog in Animals | Alpaca_ LTA ( ortholog_one2one ) Dog_ LTA ( ortholog_one2one ) GuineaPig_ LTA ( ortholog_one2one ) Macaque_ LTA ( ortholog_one2one ) Mouse_ Lta ( ortholog_one2one ) Pig_ LTA ( ortholog_one2one ) Rat_ Lta ( ortholog_one2one ) Rabbit_ TNLG1E ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNF, LTB, TNFSF15, TNFSF14, FASLG, TNFSF10, TNFSF11, CD40LG |
| Tissue | lymph.node, appendix |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1TNR (X-ray 2.85A ) 4MXV (X-ray 3.20A ) 4MXW (X-ray 3.60A ) |
| DBSNP | rs2229094 rs2229092 rs1041981 |
| Subcellular location [CC] | Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated. |
| Mouse PG classification | NA |
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