| Gene Information | |
|---|---|
| Gene Name | LSS |
| Organism | Homo sapiens (Human) |
| Gene Length | 732 |
| Protein Names | Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC) |
| Target Name | lanosterol synthase |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000160285 ) 3 ( ENSG00000281289 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P48449 |
| Gene Card | LSS |
| Uniprot ID | P48449 |
| Pfam | PF13243; PF13249 |
| In ASD | no |
| Allosteric Prediction | yes (0.400631459) |
| Ortholog in Animals | Alpaca_ LSS ( ortholog_one2one ) Dog_ LSS ( ortholog_one2one ) GuineaPig_ LSS ( ortholog_one2one ) Macaque_ LSS ( ortholog_one2one ) Mouse_ Lss ( ortholog_one2one ) Pig_ LSS ( ortholog_one2one ) Rat_ Lss ( ortholog_one2one ) Rabbit_ LSS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in the hair bulb, the outer root sheath and hair matrix of the hair follicle epithelium. Also detected in dermal papilla, epidermis, sweat glands, sebaceous glands, and blood vessels. {ECO:0000269|PubMed:30401459}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.228866(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1W6J (X-ray 2.20A ) 1W6K (X-ray 2.10A ) |
| DBSNP | rs2839158 rs754230211 rs1260995701 rs34115287 rs1249530918 rs864622780 rs561449819 rs35785446 rs2254524 rs17293705 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:14766201, ECO:0000269|PubMed:15525992, ECO:0000269|PubMed:30401459}; Peripheral membrane protein {ECO:0000269|PubMed:14766201, ECO:0000269|PubMed:15525992}. |
| Mouse PG classification | HPG |
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