| Gene Information | |
|---|---|
| Gene Name | FAIM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 316 |
| Protein Names | Protein lifeguard 2 (Fas apoptotic inhibitory molecule 2) (Neural membrane protein 35) (Transmembrane BAX inhibitor motif-containing protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000135472 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9BWQ8 |
| Gene Card | FAIM2 |
| Uniprot ID | Q9BWQ8 |
| Pfam | PF01027 |
| In ASD | no |
| Allosteric Prediction | no (-0.5976598) |
| Ortholog in Animals | Alpaca_ FAIM2 ( ortholog_one2one ) Dog_ FAIM2 ( ortholog_one2one ) GuineaPig_ FAIM2 ( ortholog_one2one ) Macaque_ FAIM2 ( ortholog_one2one ) Mouse_ Faim2 ( ortholog_one2one ) Pig_ FAIM2 ( ortholog_one2one ) Rat_ Faim2 ( ortholog_one2one ) Rabbit_ FAIM2 ( ortholog_one2one ) |
| Ohnologs | TMBIM1, GRINA |
| Paralogs | TMBIM1, GRINA, GHITM, TMBIM4, TMBIM6 |
| Tissue | cerebral.cortex, brain |
| Tissue Specificity | Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus. {ECO:0000269|PubMed:10535980, ECO:0000269|PubMed:20336406}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane raft {ECO:0000269|PubMed:17635665}. Postsynaptic cell membrane {ECO:0000250}. |
| Mouse PG classification | NA |
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