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Gene Information
Gene Name
LSD1
Organism
Homo sapiens (Human)
Gene Length
852
Protein Names
Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)
Target Name
NA
Target Type
NA
Gene Age
NA
Evolutionary Stage
NA
AlphaFoldDB
O60341
Gene Card
KDM1A
Uniprot ID
O60341
Pfam
PF01593; PF04433
In ASD
yes
Allosteric Prediction
NA
Ortholog in Animals
NA
Ohnologs
NA
Paralogs
NA
Tissue
NA
Tissue Specificity
Ubiquitously expressed. {ECO:0000269|PubMed:16079795}.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.034862(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
2COM
(NMR
-
)
2DW4
(X-ray
2.30A
)
2EJR
(X-ray
2.70A
)
2H94
(X-ray
2.90A
)
2HKO
(X-ray
2.80A
)
2IW5
(X-ray
2.57A
)
2L3D
(NMR
-
)
2UXN
(X-ray
2.72A
)
2UXX
(X-ray
2.74A
)
2V1D
(X-ray
3.10A
)
2X0L
(X-ray
3.00A
)
2XAF
(X-ray
3.25A
)
2XAG
(X-ray
3.10A
)
2XAH
(X-ray
3.10A
)
2XAJ
(X-ray
3.30A
)
2XAQ
(X-ray
3.20A
)
2XAS
(X-ray
3.20A
)
2Y48
(X-ray
3.00A
)
2Z3Y
(X-ray
2.25A
)
2Z5U
(X-ray
2.25A
)
3ABT
(X-ray
3.20A
)
3ABU
(X-ray
3.10A
)
3ZMS
(X-ray
2.96A
)
3ZMT
(X-ray
3.10A
)
3ZMU
(X-ray
3.20A
)
3ZMV
(X-ray
3.00A
)
3ZMZ
(X-ray
3.00A
)
3ZN0
(X-ray
2.80A
)
3ZN1
(X-ray
3.10A
)
4BAY
(X-ray
3.10A
)
4CZZ
(X-ray
3.00A
)
4KUM
(X-ray
3.05A
)
4UV8
(X-ray
2.80A
)
4UV9
(X-ray
3.00A
)
4UVA
(X-ray
2.90A
)
4UVB
(X-ray
2.80A
)
4UVC
(X-ray
3.10A
)
4UXN
(X-ray
2.85A
)
4XBF
(X-ray
2.80A
)
5AFW
(X-ray
1.60A
)
5H6Q
(X-ray
2.53A
)
5H6R
(X-ray
2.60A
)
5IT3
(X-ray
1.40A
)
5L3B
(X-ray
3.30A
)
5L3C
(X-ray
3.31A
)
5L3D
(X-ray
2.60A
)
5L3E
(X-ray
2.80A
)
5L3F
(X-ray
3.50A
)
5L3G
(X-ray
3.10A
)
5LBQ
(X-ray
3.30A
)
5LGN
(X-ray
3.20A
)
5LGT
(X-ray
3.00A
)
5LGU
(X-ray
3.20A
)
5LHG
(X-ray
3.34A
)
5LHH
(X-ray
3.05A
)
5LHI
(X-ray
3.40A
)
5X60
(X-ray
2.69A
)
5YJB
(X-ray
2.96A
)
6E1F
(X-ray
1.16A
)
6K3E
(X-ray
2.87A
)
6KGK
(X-ray
2.70A
)
6KGL
(X-ray
2.70A
)
6KGM
(X-ray
2.62A
)
6KGN
(X-ray
2.62A
)
6KGO
(X-ray
2.25A
)
6KGP
(X-ray
2.25A
)
6KGQ
(X-ray
2.32A
)
6KGR
(X-ray
2.32A
)
6NQM
(X-ray
2.90A
)
6NQU
(X-ray
2.70A
)
6NR5
(X-ray
2.90A
)
6S35
(X-ray
3.10A
)
6TE1
(X-ray
3.11A
)
6TUY
(X-ray
2.60A
)
6VYP
(X-ray
4.99A
)
6W4K
(X-ray
2.93A
)
6WC6
(X-ray
3.10A
)
7CDC
(X-ray
2.64A
)
7CDD
(X-ray
2.76A
)
7CDE
(X-ray
2.68A
)
7CDF
(X-ray
2.68A
)
7CDG
(X-ray
2.80A
)
7E0G
(X-ray
2.25A
)
7JJL
(X-ray
2.60A
)
7JJM
(X-ray
2.06A
)
7JK7
(X-ray
1.96A
)
7VQS
(X-ray
2.94A
)
7VQT
(X-ray
2.91A
)
7VQU
(X-ray
2.94A
)
DBSNP
rs864309715
rs864309716
rs864309714
Subcellular location [CC]
Nucleus {ECO:0000269|PubMed:11102443, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:33980486}.
Mouse PG classification
NA
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