Gene Information
Gene NameSPTBN2
OrganismHomo sapiens (Human)
Gene Length2390
Protein NamesSpectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000173898 )
Evolutionary StageEukaryota
AlphaFoldDBO15020
Gene CardSPTBN2
Uniprot IDO15020
PfamPF00307; PF15410; PF00435
In ASDno
Allosteric Predictionyes (0.811222077)
Ortholog in AnimalsAlpaca_ SPTBN2 ( ortholog_one2one )
Dog_ SPTBN2 ( ortholog_one2one )
GuineaPig_ SPTBN2 ( ortholog_one2one )
Macaque_ SPTBN2 ( ortholog_one2one )
Mouse_ Sptbn2 ( ortholog_one2one )
Pig_ SPTBN2 ( ortholog_one2one )
Rat_ Sptbn2 ( ortholog_one2one )
Rabbit_ SPTBN2 ( ortholog_one2one )
OhnologsSPTB, SPTBN1
ParalogsDSP, SPTBN5, ACTN4, MICAL2, DMD, SYNE3, GAS2L2, FLNB, SPTAN1, SYNE2, PLEC, EPPK1, SYNE1, CLMN, DYTN, MICAL3, PKHD1, SMTNL2, DRP2, UTRN, PKHD1L1, ACTN2, ACTN3, MICAL1, SPTBN1, MACF1, ACTN1, DST, SPTB, GAS2L3, FLNC, FLNA, DTNA, SPTA1, DTNB, SPTBN4
TissueNA
Tissue SpecificityHighly expressed in brain, kidney, pancreas, and liver, and at lower levels in lung and placenta.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1WJM  (NMR  1WYQ  (NMR  6ANU  (EM  7.00A 
DBSNP rs121918306  rs397514749  rs4930388  rs36054877  rs506028 
Subcellular location [CC]Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Mouse PG classificationHPG
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