Gene Information
Gene NameLRRK2
OrganismHomo sapiens (Human)
Gene Length2527
Protein NamesLeucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Target Nameleucine-rich repeat serine/threonine-protein kinase 2
Target TypeNA
Gene Age680 ( ENSG00000188906 )
Evolutionary StageEukaryota
AlphaFoldDBQ5S007
Gene CardLRRK2
Uniprot IDQ5S007
PfamPF16095; PF12799; PF13855; PF00069
In ASDyes
Allosteric Predictionyes (0.543327659)
Ortholog in AnimalsAlpaca_ LRRK2 ( ortholog_one2one )
Dog_ LRRK2 ( ortholog_one2one )
GuineaPig_ LRRK2 ( ortholog_one2one )
Macaque_ LRRK2 ( ortholog_one2one )
Mouse_ Lrrk2 ( ortholog_one2one )
Pig_ LRRK2 ( ortholog_one2one )
Rat_ Lrrk2 ( ortholog_one2one )
Rabbit_ LRRK2 ( ortholog_one2one )
OhnologsLRRK1
ParalogsLIMK2, RIPK1, TNNI3K, TESK2, KSR2, MAP3K10, RIPK2, MOS, MAP3K9, MLKL, MAP3K20, ARAF, TESK1, MAP3K13, BRAF, ILK, MAP3K11, RAF1, MAP3K12, MAP3K21, LIMK1, KSR1, RIPK3
Tissuelung
Tissue SpecificityExpressed in pyramidal neurons in all cortical laminae of the visual cortex, in neurons of the substantia nigra pars compacta and caudate putamen (at protein level). Expressed in neutrophils (at protein level) (PubMed:29127255). Expressed in the brain. Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas. {ECO:0000269|PubMed:15541308, ECO:0000269|PubMed:15541309, ECO:0000269|PubMed:16532471, ECO:0000269|PubMed:17120249, ECO:0000269|PubMed:29127255}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.003638(Rat);0.003361(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2ZEJ  (X-ray  2.00A  )  3D6T  (X-ray  2.43A  )  5MY9  (X-ray  1.33A  )  5MYC  (X-ray  1.46A  )  6DLO  (X-ray  2.70A  )  6DLP  (X-ray  4.00A  )  6OJE  (X-ray  1.95A  )  6OJF  (X-ray  1.60A  )  6VNO  (EM  3.50A  )  6VP6  (EM  3.47A  )  6VP7  (EM  3.50A  )  6XAF  (X-ray  1.97A  )  6XR4  (EM  14.00A  )  7LHT  (EM  3.50A  )  7LHW  (EM  3.70A  )  7LI3  (EM  3.80A  )  7LI4  (EM  3.10A  ) 
DBSNP rs2256408  rs33995463  rs56108242  rs34594498  rs7308720  rs199566791  rs281865043  rs10878307  rs34410987  rs35173587  rs281865044  rs281865045  rs17519916  rs111341148  rs76535406  rs34805604  rs60185966  rs4640000  rs17466213  rs28365226  rs7133914  rs33939927  rs33939927  rs34995376  rs35507033  rs33958906  rs200212150  rs721710  rs33949390  rs35303786  rs11564148  rs35801418  rs145364431  rs145364431  rs35602796  rs281865053  rs77428810  rs34015634  rs34637584  rs35870237  rs78029637  rs33995883  rs12423862  rs111691891  rs201271001  rs72547981  rs35658131  rs12581902  rs113511708  rs34778348  rs79546190  rs78964014  rs3761863  rs72547983  rs281865057 
Subcellular location [CC]Cytoplasmic vesicle {ECO:0000269|PubMed:16321986, ECO:0000269|PubMed:16352719, ECO:0000269|PubMed:26014385}. Perikaryon {ECO:0000269|PubMed:17120249}. Golgi apparatus membrane {ECO:0000269|PubMed:16321986, ECO:0000269|PubMed:23395371};
Peripheral membrane protein {ECO:0000269|PubMed:16321986}. Cell projection, axon {ECO:0000269|PubMed:17120249}. Cell projection, dendrite {ECO:0000269|PubMed:17120249, ECO:0000269|PubMed:21850687}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16321986, ECO:0000269|PubMed:25201882};
Peripheral membrane protein {ECO:0000269|PubMed:16321986}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:24687852}. Endosome {ECO:0000250|UniProtKB:Q5S006}. Lysosome {ECO:0000269|PubMed:17120249}. Mitochondrion outer membrane {ECO:0000269|PubMed:16269541, ECO:0000269|PubMed:16321986, ECO:0000269|PubMed:17120249, ECO:0000269|PubMed:29212815};
Peripheral membrane protein {ECO:0000269|PubMed:16269541, ECO:0000269|PubMed:16321986, ECO:0000269|PubMed:17120249, ECO:0000269|PubMed:29212815}. Note=Colocalized with RAB29 along tubular structures emerging from Golgi apparatus (PubMed:23395371). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:25201882). {ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:25201882}.
Mouse PG classificationNA
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