| Gene Information | |
|---|---|
| Gene Name | PI4K2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 479 |
| Protein Names | Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000155252 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9BTU6 |
| Gene Card | PI4K2A |
| Uniprot ID | Q9BTU6 |
| Pfam | PF00454 |
| In ASD | no |
| Allosteric Prediction | no (-0.316490689) |
| Ortholog in Animals | Alpaca_ PI4K2A ( ortholog_one2one ) Dog_ PI4K2A ( ortholog_one2one ) GuineaPig_ PI4K2A ( ortholog_one2one ) Macaque_ PI4K2A ( ortholog_one2one ) Mouse_ Pi4k2a ( ortholog_one2one ) Pig_ PI4K2A ( ortholog_one2one ) Rat_ Pi4k2a ( ortholog_one2one ) Rabbit_ PI4K2A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PI4K2B |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine. {ECO:0000269|PubMed:11279162}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4HND (X-ray 3.20A ) 4HNE (X-ray 2.95A ) 4PLA (X-ray 2.77A ) 4YC4 (X-ray 2.58A ) 5EUT (X-ray 2.80A ) 5I0N (X-ray 2.28A ) |
| DBSNP | NA |
| Subcellular location [CC] | Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12324459, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:22535966}; Lipid-anchor {ECO:0000269|PubMed:22535966}. Membrane raft {ECO:0000269|PubMed:11279162}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q2TBE6}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q2TBE6}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q2TBE6}. Mitochondrion {ECO:0000250|UniProtKB:Q2TBE6}. Endosome {ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:23146885}. Cytoplasmic vesicle {ECO:0000269|PubMed:16443754}. Membrane {ECO:0000269|PubMed:24675427}; Lipid-anchor {ECO:0000269|PubMed:24675427}. Cell membrane {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754}. Perikaryon {ECO:0000250|UniProtKB:Q2TBE6}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q2TBE6}. Note=Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. Transported from neuronal cell body to neuron projections and neurite tips in a BLOC-1- and AP-3-complexes-dependent manner. {ECO:0000250|UniProtKB:Q2TBE6}. |
| Mouse PG classification | NA |
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