Gene Information
Gene NameLRRC8D
OrganismHomo sapiens (Human)
Gene Length858
Protein NamesVolume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000171492 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ7L1W4
Gene CardLRRC8D
Uniprot IDQ7L1W4
PfamPF13855; PF12534
In ASDno
Allosteric Predictionno (-1.090012946)
Ortholog in AnimalsDog_ LRRC8D ( ortholog_one2one )
GuineaPig_ LRRC8D ( ortholog_one2one )
Macaque_ LRRC8D ( ortholog_one2one )
Mouse_ Lrrc8d ( ortholog_one2one )
Pig_ LRRC8D ( ortholog_one2one )
Rat_ Lrrc8d ( ortholog_one2one )
Rabbit_ LRRC8D ( ortholog_one2one )
OhnologsLRRC8A, LRRC8E
ParalogsLRRC8B, LRRIQ4, LRRC18, LRCH4, LRRK1, LRRC58, LRRD1, PHLPP1, ERBIN, LRRC8C, LRCH2, MFHAS1, SCRIB, LRRC1, LRRC2, PIDD1, LRRC30, LRRC27, LRRC8E, LRRC7, LRCH1, LRRC10, LRRC10B, LRRC40, SHOC2, PHLPP2, LRCH3, LRRC69, LRRC39, LRRC28, LRRC8A
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6M04  (EM  4.36A  ) 
DBSNP rs11552246 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:28193731};
Multi-pass membrane protein {ECO:0000269|PubMed:32415200}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24782309, ECO:0000305|PubMed:24790029};
Multi-pass membrane protein {ECO:0000269|PubMed:32415200}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:24782309, PubMed:24790029). Requires LRRC8A for expression at the cell membrane (PubMed:24790029). {ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029}.
Mouse PG classificationNA
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