| Gene Information | |
|---|---|
| Gene Name | LRRC4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 653 |
| Protein Names | Leucine-rich repeat-containing protein 4 (Brain tumor-associated protein BAG) (Nasopharyngeal carcinoma-associated gene 14 protein) (Netrin-G2 ligand) (NGL-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000128594 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9HBW1 |
| Gene Card | LRRC4 |
| Uniprot ID | Q9HBW1 |
| Pfam | PF07679; PF13855 |
| In ASD | no |
| Allosteric Prediction | no (-0.357666282) |
| Ortholog in Animals | Alpaca_ LRRC4 ( ortholog_one2one ) Dog_ LRRC4 ( ortholog_one2one ) GuineaPig_ LRRC4 ( ortholog_one2one ) Macaque_ LRRC4 ( ortholog_one2one ) Mouse_ Lrrc4 ( ortholog_one2one ) Pig_ LRRC4 ( ortholog_one2one ) Rat_ Lrrc4 ( ortholog_one2one ) Rabbit_ LRRC4 ( ortholog_one2one ) |
| Ohnologs | LRRC4B, LRRC4C |
| Paralogs | LRTM1, LRRTM3, BGN, LRRTM1, LRRC19, RTN4RL2, LRRC4B, NYX, PODN, LRRC15, FLRT2, FLRT1, LRRTM4, LRRC66, RTN4RL1, ASPN, PODNL1, FLRT3, DCN, GP1BA, RTN4R, LRRC4C |
| Tissue | NA |
| Tissue Specificity | Specifically expressed in brain. {ECO:0000269|PubMed:15967442}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DL9 (NMR - ) 3ZYI (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. Postsynaptic cell membrane {ECO:0000250}. Note=LRRC4 and DLG4 are interdependent for synaptic localization. {ECO:0000250}. |
| Mouse PG classification | NA |
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