| Gene Information | |
|---|---|
| Gene Name | LRRC26 |
| Organism | Homo sapiens (Human) |
| Gene Length | 334 |
| Protein Names | Leucine-rich repeat-containing protein 26 (BK channel auxiliary gamma subunit LRRC26) (Cytokeratin-associated protein in cancer) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000184709 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q2I0M4 |
| Gene Card | LRRC26 |
| Uniprot ID | Q2I0M4 |
| Pfam | PF13855 |
| In ASD | no |
| Allosteric Prediction | no (-0.907732918) |
| Ortholog in Animals | Alpaca_ LRRC26 ( ortholog_one2one ) GuineaPig_ LRRC26 ( ortholog_one2one ) Macaque_ LRRC26 ( ortholog_one2one ) Mouse_ Lrrc26 ( ortholog_one2one ) Pig_ LRRC26 ( ortholog_one2one ) Rat_ Lrrc26 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LRG1, CPN2, LRRTM2, LRRC52, LRIT3, LRRC24, ELFN2, LRIG3, LGR6, LGR5, CHAD, CHADL, LRIT1, TRIL, ELFN1, LGR4, LGI2, LGI1, LRIG2, LRIG1, LGI3, LGI4 |
| Tissue | colon, prostate, salivary.gland, parotid.gland, submandibular.gland, minor.salivary.gland |
| Tissue Specificity | Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines. {ECO:0000269|PubMed:16585525, ECO:0000269|PubMed:19250639}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels. {ECO:0000269|PubMed:15164053}. |
| Mouse PG classification | NA |
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