| Gene Information | |
|---|---|
| Gene Name | GCN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2671 |
| Protein Names | eIF-2-alpha kinase activator GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000089154 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92616 |
| Gene Card | GCN1 |
| Uniprot ID | Q92616 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.242460247) |
| Ortholog in Animals | Alpaca_ GCN1 ( ortholog_one2one ) Dog_ GCN1 ( ortholog_one2one ) GuineaPig_ GCN1 ( ortholog_one2one ) Macaque_ GCN1 ( ortholog_one2one ) Mouse_ Gcn1 ( ortholog_one2one ) Pig_ GCN1 ( ortholog_one2one ) Rat_ Gcn1 ( ortholog_one2one ) Rabbit_ GCN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ECPAS |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed (PubMed:9039502). Expressed in skeletal muscules, ovary and testis (PubMed:9234705). {ECO:0000269|PubMed:9039502, ECO:0000269|PubMed:9234705}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002054(Rat);0.040816(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3864938 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:E9PVA8}. Note=Associates with ribosomes in undifferentiated neuroblastoma cells and increases after neuronal differentiation. {ECO:0000250|UniProtKB:E9PVA8}. |
| Mouse PG classification | NA |
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