| Gene Information | |
|---|---|
| Gene Name | SYT4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 425 |
| Protein Names | Synaptotagmin-4 (Synaptotagmin IV) (SytIV) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000132872 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H2B2 |
| Gene Card | SYT4 |
| Uniprot ID | Q9H2B2 |
| Pfam | PF00168 |
| In ASD | no |
| Allosteric Prediction | no (-0.367711716) |
| Ortholog in Animals | Alpaca_ SYT4 ( ortholog_one2one ) Dog_ SYT4 ( ortholog_one2one ) GuineaPig_ SYT4 ( ortholog_one2one ) Macaque_ SYT4 ( ortholog_one2one ) Mouse_ Syt4 ( ortholog_one2one ) Pig_ SYT4 ( ortholog_one2one ) Rat_ Syt4 ( ortholog_one2one ) Rabbit_ SYT4 ( ortholog_one2one ) |
| Ohnologs | SYT11 |
| Paralogs | SYT2, SYTL3, SYT13, TC2N, SYT1, SYT7, SYTL4, SYTL5, DOC2B, DOC2A, SYT14, C2CD4C, SYTL1, RPH3A, SYT8, SYT11, SYT12, C2CD4A, C2CD4B, RPH3AL, SYT15, SYT15B, SYT9, SYT16, SYT6, C2CD4D, SYT3, SYTL2, SYT10, SYT5, SYT17 |
| Tissue | brain, cerebral.cortex, adrenal.gland, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Expressed in melanocytes (PubMed:23999003). Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1UGK (NMR - ) |
| DBSNP | rs16977447 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250|UniProtKB:P50232}; Single-pass membrane protein {ECO:0000250|UniProtKB:P50232}. |
| Mouse PG classification | NA |
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