| Gene Information | |
|---|---|
| Gene Name | LRP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 963 |
| Protein Names | Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000157193 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14114 |
| Gene Card | LRP8 |
| Uniprot ID | Q14114 |
| Pfam | PF00057; PF00058 |
| In ASD | no |
| Allosteric Prediction | no (-0.229066751) |
| Ortholog in Animals | Alpaca_ LRP8 ( ortholog_one2one ) Dog_ LRP8 ( ortholog_one2one ) GuineaPig_ LRP8 ( ortholog_one2one ) Macaque_ LRP8 ( ortholog_one2one ) Mouse_ Lrp8 ( ortholog_one2one ) Pig_ LRP8 ( ortholog_one2one ) Rat_ Lrp8 ( ortholog_one2one ) Rabbit_ LRP8 ( ortholog_one2one ) |
| Ohnologs | LDLR, VLDLR |
| Paralogs | LDLR, LRP12, LRP2, EGF, LRP1, VLDLR, LRP4, LRP5, LRP1B, NID2, LRP6, LRP3, LRP10, NID1 |
| Tissue | testis, thyroid, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver. {ECO:0000269|PubMed:10218790, ECO:0000269|PubMed:10508213}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3A7Q (X-ray 2.60A ) 5B4X (X-ray 3.20A ) 5B4Y (X-ray 1.90A ) |
| DBSNP | rs4926972 rs3820198 rs5180 rs5181 rs5172 rs5170 rs5171 rs5172 rs5174 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:30873003}; Single-pass type I membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment. {ECO:0000250}. |
| Mouse PG classification | NA |
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