| Gene Information | |
|---|---|
| Gene Name | LRP7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1615 |
| Protein Names | Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O75197 |
| Gene Card | LRP5 |
| Uniprot ID | O75197 |
| Pfam | PF00057; PF00058 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with the highest level of expression in the liver and in aorta. {ECO:0000269|PubMed:9790987}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.075(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1197978360 rs41494349 rs143433231 rs368198391 rs80358305 rs121908669 rs121908668 rs80358306 rs760548029 rs121908671 rs121908672 rs121908670 rs397514665 rs121908673 rs1219101402 rs1320065036 rs1158745675 rs1332274863 rs201320326 rs750791263 rs1273567061 rs774342727 rs757888034 rs376152274 rs80358308 rs373910016 rs930355318 rs866606166 rs1318906451 rs121908664 rs545508982 rs1245625202 rs80358309 rs80358310 rs80358311 rs377144001 rs80358312 rs121908665 rs80358313 rs80358314 rs989864153 rs758976409 rs4988321 rs1470530779 rs1339222045 rs746701187 rs121908674 rs80358316 rs765952535 rs1398692057 rs369471051 rs61889560 rs377258285 rs80358317 rs143396225 rs724159825 rs80358318 rs141178995 rs11607268 rs768615287 rs3736228 rs80358320 rs28939709 rs201030241 rs1127291 rs144376510 rs141407040 rs150862227 rs724159827 |
| Subcellular location [CC] | Membrane {ECO:0000250|UniProtKB:Q91VN0}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q91VN0}. Endoplasmic reticulum {ECO:0000269|PubMed:25920554}. Note=Chaperoned to the plasma membrane by MESD. {ECO:0000250|UniProtKB:Q91VN0}. |
| Mouse PG classification | NA |
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