| Gene Information | |
|---|---|
| Gene Name | LRP6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1613 |
| Protein Names | Low-density lipoprotein receptor-related protein 6 (LRP-6) |
| Target Name | ldl receptor related protein-6 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000070018 ) 3 ( ENSG00000281324 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75581 |
| Gene Card | LRP6 |
| Uniprot ID | O75581 |
| Pfam | PF00057; PF00058 |
| In ASD | no |
| Allosteric Prediction | yes (0.149789464) |
| Ortholog in Animals | Alpaca_ LRP6 ( ortholog_one2one ) Dog_ LRP6 ( ortholog_one2one ) GuineaPig_ LRP6 ( ortholog_one2one ) Macaque_ LRP6 ( ortholog_one2one ) Mouse_ Lrp6 ( ortholog_one2one ) Pig_ LRP6 ( ortholog_one2one ) Rat_ Lrp6 ( ortholog_one2one ) Rabbit_ LRP6 ( ortholog_one2one ) |
| Ohnologs | LRP5 |
| Paralogs | LDLR, LRP12, LRP2, EGF, LRP1, VLDLR, LRP4, LRP5, LRP1B, NID2, LRP3, LRP8, LRP10, NID1 |
| Tissue | NA |
| Tissue Specificity | Widely coexpressed with LRP5 during embryogenesis and in adult tissues. |
| Pharmacological Animal Models | 0.030815(Chimpanzee);0.277488(Mouse);NULL(Rat);0.031579(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3S2K (X-ray 2.80A ) 3S8V (X-ray 3.10A ) 3S8Z (X-ray 2.80A ) 3S94 (X-ray 2.80A ) 3SOB (X-ray 1.90A ) 3SOQ (X-ray 1.90A ) 3SOV (X-ray 1.27A ) 4A0P (X-ray 1.90A ) 4DG6 (X-ray 2.90A ) 4NM5 (X-ray 2.30A ) 4NM7 (X-ray 2.30A ) 5AIR (X-ray 2.53A ) 5FWW (X-ray 3.50A ) 5GJE (EM 21.00A ) 6H15 (X-ray 2.60A ) 6H16 (X-ray 2.90A ) 6L6R (X-ray 3.80A ) 7NAM (X-ray 1.60A ) |
| DBSNP | rs864309648 rs141212743 rs397515473 rs397515474 rs7975614 rs121918313 rs2302686 rs2302685 rs34815107 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:26387593}; Single-pass type I membrane protein. Endoplasmic reticulum {ECO:0000269|PubMed:26387593}. Membrane raft {ECO:0000269|PubMed:23987510}. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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