| Gene Information | |
|---|---|
| Gene Name | LRP4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1905 |
| Protein Names | Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000134569 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75096 |
| Gene Card | LRP4 |
| Uniprot ID | O75096 |
| Pfam | PF12662; PF00057; PF00058 |
| In ASD | yes |
| Allosteric Prediction | yes (0.527089596) |
| Ortholog in Animals | Alpaca_ LRP4 ( ortholog_one2one ) Dog_ LRP4 ( ortholog_one2one ) GuineaPig_ LRP4 ( ortholog_one2one ) Macaque_ LRP4 ( ortholog_one2one ) Mouse_ Lrp4 ( ortholog_one2one ) Pig_ LRP4 ( ortholog_one2one ) Rat_ Lrp4 ( ortholog_one2one ) Rabbit_ LRP4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LDLR, LRP12, LRP2, EGF, LRP1, VLDLR, LRP5, LRP1B, NID2, LRP6, LRP3, LRP8, LRP10, NID1 |
| Tissue | NA |
| Tissue Specificity | Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain. {ECO:0000269|PubMed:21471202}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs267607222 rs267607221 rs7926667 rs267607224 rs267607223 rs267607220 rs6485702 rs387906884 rs387906883 rs2306033 rs786205153 rs2306031 rs746136135 rs2306029 rs3816614 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q8VI56}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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